This 2020 electron microscope made available by the U.S. Centers for Disease Control and Prevention image shows the spherical coronavirus particles from the first U.S. case of COVID-19. A recent study sparked some worry last week when it revealed a mutation “of urgent concern” in the virus responsible for COVID-19. But experts say more research is needed to determine what that really means.The preliminary, non peer-reviewed study from the Los Alamos National Laboratory in New Mexico indicated that a COVID-19 strand containing a specific mutation — on the spike protein D614G — is emerging as the dominant form of the virus. THE CANADIAN PRESS/AP-C.S. Goldsmith, A. Tamin/ CDC via AP

This 2020 electron microscope made available by the U.S. Centers for Disease Control and Prevention image shows the spherical coronavirus particles from the first U.S. case of COVID-19. A recent study sparked some worry last week when it revealed a mutation “of urgent concern” in the virus responsible for COVID-19. But experts say more research is needed to determine what that really means.The preliminary, non peer-reviewed study from the Los Alamos National Laboratory in New Mexico indicated that a COVID-19 strand containing a specific mutation — on the spike protein D614G — is emerging as the dominant form of the virus. THE CANADIAN PRESS/AP-C.S. Goldsmith, A. Tamin/ CDC via AP

Halifax lab team to conduct first Canadian trials for possible COVID-19 vaccine

Lab was involved in trials that led to creation of Ebola vaccine

The first Canadian clinical trials for a possible COVID-19 vaccine will be conducted by a Halifax research team that also was involved in trials that eventually led to a vaccine for the Ebola virus.

Health Canada has approved trials that will be conducted at the Canadian Centre for Vaccinology at Dalhousie University.

The centre’s director, Dr. Scott Halperin, says the lab was one of several in Canada and the U.S. whose work starting in 2014 eventually saw an “emergency release” of an Ebola vaccine that was used in West Africa before a third phase of clinical trials had been completed.

Halperin said each lab did slightly different studies in order to get the right type of information before quickly moving to the second phase and then the third.

“The Phase 1 studies were done and within six months the data were available and the phase three studies were started in West Africa which then helped to actually stop the epidemic,” he said in an interview.

Halperin said it’s possible the same emergency release could happen in Canada with a potential COVID-19 vaccine if it shows potential and is deemed safe, expediting a process that usually takes a number of years to complete — anywhere from five to seven years under normal circumstances.

“That would be something that Health Canada and the Canadian government would have to decide whether they wanted to do that. But it is certainly one of the options in the tool kit of things they can do to expedite the process if this or any other vaccine is looking promising.”

READ MORE: First clinical trial for potential COVID-19 vaccine in Canada approved: Trudeau

Halperin pointed out that despite its early use during testing, the Ebola vaccine wasn’t actually licensed as a regular marketed vaccine until late last year.

However, he cautions there’s much work to be done before a COVID-19 vaccine could be approved for use.

The Halifax researchers will be following up work by Chinese manufacturer CanSino Biologics, which is already conducting human clinical trials for the vaccine.

Halperin said the first phase trial should be underway within the next three weeks once final approval is given by the centre’s research ethics board.

Phase 1 will involve fewer than 100 healthy volunteers between the ages of 18 and 55 who will be followed over the next six months.

“We want to make sure that the vaccine is safe first in younger individuals before we go into people who may be at higher risk,” Halperin said.

The participants are given a dose of the vaccine and are clinically monitored through a series of blood tests. They are also asked to record their symptoms in a diary so the researchers can have even more information.

“We collect any type of symptoms they might have whether they think it’s related to the vaccine or not,” said Halperin.

Each participant will make between nine and 13 visits to the centre during the first phase of the study.

If the initial test group shows a safe immune response to the vaccine, Halperin said researchers will quickly transition into an expanded second phase study before the first phase is even completed.

That would involve hundreds of people of all ages, including those aged 65 to 85, and would be administered by several other research centres across the country that are part of the Canadian Immunization Research Network.

Halperin said the network was set up by the federal government in 2009 as part of the response to the H1N1 pandemic. He said the intent was to create the necessary infrastructure to respond rapidly to an emergency and to do early phase clinical trials so vaccines would be available in Canada.

“This is a good test of that (network),” Halperin said of clinical trials that will be the first of “many more to come.”

Keith Doucette, The Canadian Press


Like us on Facebook and follow us on Twitter.

Want to support local journalism during the pandemic? Make a donation here.

CanadaCoronavirusvaccines

Get local stories you won't find anywhere else right to your inbox.
Sign up here

Just Posted

B.C. is conducting an emergency alert test on Nov. 25 at 1:55 p.m. (Black Press Media File photo)
Expect B.C.-wide emergency alert system test Wednesday afternoon

The message will be broadcast at 1:55 p.m. on Nov. 25.

The Grinch was spotted on a tractor in Metchosin Monday morning, an early welcome for the holiday season. (Aaron Guillen/News Staff)
PHOTO: Grinch arrives early for the holidays in Metchosin

Send your favourite Christmas decorations to Black Press Media

file
Oak Bay resident bilked $3,300 in puppy scam

Three cases of fraud reported in two days

Sidney’s Star Cinema has temporarily closed as part of efforts to COVID-19. (Black Press Media File).
Sidney’s Star Cinema temporarily goes dark

Closure reflects provincial health order in effect until Dec. 7

Victoria police are asking for help locating Jordan Doddridge who is wanted on a Canada-wide warrant. (Courtesy of Victoria Police Department)
VicPD seek help locating man wanted on Canada-wide warrant

Jordan Doddridge has an extensive criminal history including violent offences

Provincial health officer Dr. Bonnie Henry updates B.C.’s COVID-19 situation at the B.C. legislature, Nov. 23, 2020. (B.C. government)
B.C. daily COVID-19 cases hits record 941 on Tuesday

Further restrictions on indoor exercise take effect

(Pixabay.com)
Man, 28, warned by Kootenay police to stop asking people to marry him

A woman initially reported the incident to police before they discovered others had been popped the question

Winston Blackmore (left) and James Oler (right) were sentenced on separate charges of polygamy this week in Cranbrook Supreme Court.
No more charges expected in Bountiful investigation, special prosecutor says

Special prosecutor says mandate has ended following review of evidence from Bountiful investigations

(Ashley Wadhwani/Black Press Media)
Refuse to follow B.C.’s mask mandate? Face a $230 fine

Masks are now required to be worn by all British Columbians, 12 years and older

Parksville’s French Creek Harbour experienced a diesel spill on Nov. 23 after a barge and fishing vessel collided. (Mandy Moraes photo)
Coast Guard cleans up diesel spill in Parksville’s French Creek Harbour

Barge carrying fuel truck collides with fishing vessel

Stock photo
Senior from Gibsons caught viewing child porn sentenced to 10 months

74-year-old pleaded guilty after police seized 1,500-2,500 images

BC Teachers' Federation President Teri Mooring is asking parents of school-aged children to encourage the wearing of masks when possible in schools. (THE CANADIAN PRESS/Chad Hipolito)
LETTER: Teachers union encourages culture of mask wearing in B.C. schools

BCTF President Teri Mooring asks parents to talk with children about wearing masks in school

Prime Minister Justin Trudeau speak to the media about the COVID-19 virus outside Rideau Cottage in Ottawa, Friday, Nov. 20, 2020. THE CANADIAN PRESS/Adrian Wyld
Canada’s inability to manufacture vaccines in-house will delay distribution: Trudeau

First doses of COVID-19 vaccine expected in first few months of 2021, prime minister says

(Pixabay)
All dance studios, other indoor group fitness facilities must close amid updated COVID-19 rules

Prior announcement had said everything except spin, HIIT and hot yoga could remain open

Most Read