Famous giant tortoise DNA may hold fountain of youth: UCBO

After Lonesome George’s death he still provides clues to longer life

Lonesome George was the famed last representative of a giant tortoise species once found on the Galapagos island of Pinta. Image credit: Mark Putney

Ever since Darwin’s first steps on the Galapagos Islands, understanding the adaptations that offer the giant tortoise its extended lifespan has been a tantalizing scientific pursuit.

And now, new research by an international team including researchers from UBC’s Okanagan campus has used the DNA from one famous giant tortoise to uncover the genes that are associated with their longevity. The discovery provides clues to better understand aging in humans and may help preserve the species says Michael Russello, study co-author and biology professor at UBC Okanagan.

“Giant tortoises are among the longest living vertebrate animals and have become an interesting model for studying longevity and age related-disease,” said Russello. “Even though they’re one of few animals that can live longer than 100 years, there has been surprisingly little research into the giant tortoise genome.”

RELATED: UBCO and BCIT team up to brew cannabis-infused beverages

To help identify the genes that give the giant tortoise its extended lifespan, the researchers compared the complete DNA sequence from two long-lived giant tortoises. They used samples from Lonesome George—the famed last representative of a species once found on the Galapagos island of Pinta—and from another giant tortoise species found on the Aldabra atoll, a coral island in the Indian Ocean.

RELATED: UBCO sociology class calls on Kelowna Chiefs to change “derogatory” name

By comparing the giant tortoise genomes with those from other species, including humans, they found interesting variation within genes linked to DNA repair, immune response, and cancer suppression not possessed by shorter-lived vertebrates. None of those genomic variants had been previously associated with aging, offering new avenues for further study.

While individual tortoises have remarkable longevity, Russello says the Galapagos giant tortoises do not, with all living species considered threatened or endangered. He says the results of their study could provide clues into the biological processes and adaptations that gave rise to giant tortoises in the first place, while helping to better protect these animals on the verge of disappearing altogether.

“Lonesome George was a very interesting character in his own right, embodying the plight of endangered species until his death in 2012,” said Russello. “While he inspired many while he was alive, his legacy now lives on through a story written in his DNA.”

To report a typo, email:
newstips@kelownacapnews.com
.


@KelownaCapNews
newstips@kelownacapnews.com

Like us on Facebook and follow us on Twitter.

Get local stories you won't find anywhere else right to your inbox.
Sign up here

Just Posted

Residents around Sidney’s Reay Creek Pond welcome federal remediation efforts

It is not clear yet whether Sidney will renovate nearby dam at the same time

Camp fun still offered in Greater Victoria

Easter Seals offers day camp options to replace cancelled overnight camps

Public to weigh in on Colwood Royal Bay development Monday

Application to rezone lands north of Latoria Boulevard submitted to council

Loss of UVic dog park deals a blow to socially anxious pets

Owners of non-socialized dogs seek safe space following closure of Cedar Hill Corner

Swim advisory issued at Cadboro Bay beach due to high bacteria levels

Island Health advises against water activities, swimming

VIDEO: Langford cat missing 18 months reunited with family

Blue the cat found at Victoria museum 17 kilometres from home

B.C. Ferries increasing passenger capacity after COVID-19 restrictions

Transport Canada 50-per-cent limit being phased out, no current plans to provide masks

Shellfish industry get funds to clean up at Island sites and beyond

Businesses can apply to cover half of costs to clean up so-called ‘ghost gear’

BREAKING: Amber Alert for two Quebec girls cancelled after bodies found

Romy Carpentier, 6, Norah Carpentier, 11, and their father, Martin Carpentier, missing since Wednesday

B.C. man prepares to be first to receive double-hand transplant in Canada

After the surgery, transplant patients face a long recovery

Grocers appear before MPs to explain decision to cut pandemic pay

Executives from three of Canada’s largest grocery chains have defended their decision to end temporary wage increases

Bringing support to Indigenous students and communities, while fulfilling a dream

Mitacs is a nonprofit organization that operates research and training programs

RCMP ‘disappointed’ by talk that race a factor in quiet Rideau Hall arrest

Corey Hurren, who is from Manitoba, is facing 22 charges

NHL’s Canadian hubs offer little economic benefit, but morale boost is valuable: experts

Games are slated to start Aug. 1 with six Canadian teams qualifying for the 24-team resumption of play

Most Read